By Billy Hammond (Copyright AELS)

If you haven’t read Part 1, which describes the general characteristics of E. coli, you might want to take a look at it before reading this installment. Information on enterotoxigenic (ETEC) can be found in the 2nd article in this series. See the 3rd article for a discussion of enteropathogenic (EPEC).

Transmission of E. coli as a disease is usually via the fecal-oral route. Food and water often provide transport for infections.

There are five types of E. coli infections that have been identified so far: enterotoxigenic (ETEC); enteropathogenic (EPEC); enterohemorrhagic (EHEC); enteroinvasive (EIEC); and enteroaggregative (EAEC).

3. Enterohemorrhagic E. coli (EHEC).

EHEC strains are also sometimes called shiga-toxin producing E. coli (STEC). EHEC bundle-forming pili bind to cells in the large intestine (remember that in EPEC they bind to cells in the small intestine) and produce attaching and effacing lesions. They produce Shiga-like exotoxins Type 1 or 2 that result in bloody diarrhea. The acquired shiga toxin produces cell death, edema and hemorrhage in the lamina propria layer. The resultant bleeding then enter the lumen of the intestine and cause colitis. The shiga toxin can also enter the kidneys and cause hemorrhagic uremic syndrome (HUS), which can be potentially fatal.

The infamous serotype O157:H7 belongs to this group is the most common type that results in colitis and HUS. An important distinction about the O157:H7 EHEC and the non-0157:H7 EHEC is that it does not ferment sorbitol, whereas the non-0157:H7 EHEC do. This allows for the differentiation of O157:H7.

Initial manifestations are a crampy, watery diarrhea, which progresses to visibly bloody diarrhea without the presence of a fever. HUS presents with its triad of renal failure, thrombocytopenia and microangiopathic hemolytic anemia. Antibiotics should not be used in the treatment of EHEC, due to the risk of potentiating HUS.

4. Enteroinvasive E. coli (EIEC)

EIEC infections are most common in children in developing countries. Transmission is by food, water or person-to-person contact.

Plasmid encoded virulence factors almost identical to the Shigella species allow the invasion of epithelial cells and intercellular spread by actin-based motility. The EIEC strains produce a hemolysin (HlyA).

It results in a watery diarrhea, which can later result in small volume, mucous-containing bloody feces. The infections are usually self-limiting.

References: Chamberlain, Neal. Medical Microbiology: The Big Picture: The Big Picture (LANGE The Big Picture) (Kindle Location 4645-4712). McGraw-Hill Education. Kindle Edition.

Harvey, Richard A.. Microbiology: 1 (Lippincott’s Illustrated Reviews Series) (p. 111 – 114). Lippincot (Wolters Kluwer Health)

Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon. Robbins & Cotran Pathologic Basis of Disease, (Robbins Pathology) (Kindle Location 41886-41918). Elsevier Health. Kindle Edition.

大腸菌: Escherichia coli (E. coli) 4




E. coliの病気としての伝染は通常糞口経路で行う。感染された食べ物や水が普段輸送経路となる。

今まで5種類のE. coli感染が確認されている: 腸毒性大腸菌 enterotoxigenic (ETEC);腸病原性大腸菌enteropathogenic (EPEC); 腸出血性大腸菌enterohemorrhagic (EHEC); 腸侵入性大腸菌enteroinvasive (EIEC); 及び 腸管凝集性大腸菌 enteroaggregative (EAEC)

3. 腸出血性大腸菌enterohemorrhagic (EHEC)




4. 腸侵入性大腸菌enteroinvasive (EIEC)





Books published by AELS (AELS出版書籍)


原作&翻訳:ビレー ハモンド


Majoh Gakuin & Hikari Juku – Japanese Witch Schools – English Edition (魔女学院&光塾(英語)

By Billy Hammond

迷える魔女の戦い (魔女学院&光塾シリーズ第2)

原作&翻訳:ビレー ハモンド


Lost Witch (Majoh Gakuin & Hikari Juku Series Book 2) – English Edition (迷える魔女: 魔女学院&光塾第2弾:英語版)

By Billy Hammond

幸せを運ぶ魔法のチャレンジ 魔女学院&光塾シリーズの第3(Fate & Magic Jp)

原作&翻訳:ビレー ハモンド


“Fate & Magic” Majoh Gakuin & Hikari Juku Series – Japanese Witch Schools Book 3 – English Edition (幸せを運ぶ魔法のチャレンジの英語版)

By Billy Hammond

Regressed 「過去に生きて・・・」

原作&翻訳:ビレー ハモンド


Regressed – English Edition

By Billy Hammond