By Billy Hammond (Copyright AELS)

You’ve probably heard of people taking “ACE inhibitors” for their blood pressure and might have wondered what they are. Here’s a simplified explanation on how they work.


The body has two systems for regulating blood pressure. One is the rapid baroreceptor system and the other is the slow action hormonal Renin– Angiotensin– Aldosterone System (RAAS) that regulates the blood pressure by adjusting blood volume and increases the blood pressure.


In the case of hemorrhage, the mean arterial pressure drops and special cells in the kidney secrete renin. The enzyme renin works as a catalyst to convert the Angiotensinogen in the plasma into Angiotensin I. Next, the Angiotensin Converting Enzyme (ACE) acts as a catalyst to convert the Angiotensin I to Angiotensin II mostly in the lungs.


The Angiotensin II

1) Stimulates the secretion of Aldosterone by the adrenal cortex in the adrenal glands.

This increases sodium ion (Na+) reabsorption in the kidneys, thereby increasing the extra-cellular fluid (ECF) volume, blood volume and pressure in the arteries.

2) It also increases the sodium (Na+) and hydrogen ion (H+) exchange in the kidneys.

3) It increases thirst by causing the release of Anti-diuretic Hormone (ADH) from the pituitary gland.

4) It constricts the arterioles, which causes an increase in Total Peripheral Resistance (TPR) in them and moves the blood pressure in the arteries back to normal.



ACE Inhibitors

You’ve probably heard of the use of ACE inhibitors to control high blood pressure. They block the conversion of Angiotensin I to Angiotensin II in the system above, thereby lowering the blood pressure.


ACE阻害薬 (高血圧)とRAAS


高血圧を抑えるために『ACE阻害薬 』を飲んでいる話しを聞いたことがあるかも知らない。その仕組みは簡単に書いてみた。




出血があった場合、平均動脈圧(MAP)が下がるに伴い、腎臓の特別な細胞がレニンを分泌する。酵素であるレニンの触媒活性によって血漿内のアンギオテンシノゲンが アンジオテンシンIに変換される。次に主に肺の中でアンギオテンシン変換酵素(ACE)はアンジオテンシンIをアンジオテンシンIIに変換する









ACE阻害薬 』に戻ると、それらは上記のRAASの中でアンジオテンシンIをアンジオテンシンIIへの変換を阻害する

By Billy Hammond (Copyright AELS)


Books published by AELS (AELS出版書籍)


原作&翻訳:ビレー ハモンド


Majoh Gakuin & Hikari Juku – Japanese Witch Schools – English Edition (魔女学院&光塾(英語)

By Billy Hammond

迷える魔女の戦い (魔女学院&光塾シリーズ第2)

原作&翻訳:ビレー ハモンド


Lost Witch (Majoh Gakuin & Hikari Juku Series Book 2) – English Edition (迷える魔女: 魔女学院&光塾第2弾:英語版)

By Billy Hammond

幸せを運ぶ魔法のチャレンジ 魔女学院&光塾シリーズの第3(Fate & Magic Jp)

原作&翻訳:ビレー ハモンド


“Fate & Magic” Majoh Gakuin & Hikari Juku Series – Japanese Witch Schools Book 3 – English Edition (幸せを運ぶ魔法のチャレンジの英語版)

By Billy Hammond

Regressed 「過去に生きて・・・」

原作&翻訳:ビレー ハモンド


Regressed – English Edition

By Billy Hammond